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Journal of Postgraduate Medicine
Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India
ISSN: 0022-3859 EISSN: 0022-3859
Vol. 48, No. 3, 2002, pp. 197-198
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Bioline Code: jp02066
Full paper language: English
Document type: Research Article
Document available free of charge
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Journal of Postgraduate Medicine, Vol. 48, No. 3, 2002, pp. 197-198
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Case Report - Concomitant Acral Necrosis and Haemolytic Uraemic Syndrome Following Ingestion of Quinine
Agarwal N, Cherascu B
Abstract
Thrombotic microangiopathy, which broadly includes thrombotic thrombocytopaenic purpura (TTP) and haemolytic uraemic syndrome (HUS), is a multisystemic disorder that is characterised by thrombocytopaenia, microangiopathic haemolytic anemia and ischaemic manifestations, resulting from platelet agglutination in the arterial microvasculature. Acral necrosis (distal necrosis of fingers and toes) occurs usually as a sequel to severe Raynaud's phenomenon, a vasculospastic disorder frequently related to endothelial cell dysfunction. We report a case of quinine induced TTP-HUS and acral necrosis, two distinct clinical abnormalities which have not yet been reported together in association with quinine. Both of these conditions in this case resolved promptly to treatment with corticosteroids. (J Postgrad Med 2002;48:197-198)
Keywords
Quinine, Acral Necrosis, Haemolytic Uraemic Syndrome, Corticosteroids
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