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Journal of Postgraduate Medicine
Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India
ISSN: 0022-3859 EISSN: 0022-3859
Vol. 54, No. 4, 2008, pp. 316-317
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Bioline Code: jp08106
Full paper language: English
Document type: Case Report
Document available free of charge
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Journal of Postgraduate Medicine, Vol. 54, No. 4, 2008, pp. 316-317
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Life-threatening overdose with lamotrigine, citalopram, and chlorpheniramine
Venkatraman, N.; O'Neil, D. & Hall, A.P.
Abstract
Lamotrigine is a commonly used agent for seizure control in epilepsy. There are limited data on the adverse effects of lamotrigine in overdose. We report a number of serious side-effects associated with a large overdose of lamotrigine. A 23-year-old female presented to the emergency department after taking an intentional overdose of 9.2 g of lamotrigine, 56 mg of chlorpheniramine, and 220 mg of citalopram. On admission, she had a reduced level of consciousness and electrocardiographic abnormalities; a widened QRS and a prolonged corrected QT (QTc) interval. Prompt treatment with early intubation, along with the use of magnesium for cardioprotection and administration of sodium bicarbonate may have aided in a quick recovery with a short intensive care stay and good outcome.
Keywords
Chlorpheniramine, citalopram, electrocardiography, lamotrigine, magnesium, overdose, sodium bicarbonate
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