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Journal of Postgraduate Medicine
Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India
ISSN: 0022-3859 EISSN: 0022-3859
Vol. 55, No. 4, 2009, pp. 301-304
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Bioline Code: jp09097
Full paper language: English
Document type: Review Article
Document available free of charge
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Journal of Postgraduate Medicine, Vol. 55, No. 4, 2009, pp. 301-304
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Structure-based drug design and modern medicine
Vijayakrishnan, R.
Abstract
Drug discovery has evolved through various stages into more rational and evidence-based drug designing. Compared to conventional methods which were time consuming and less logical, new drug designing based on structure is rational, evidence based, faster and more scientific in nature. In the era of modern medicine, where newer insights into molecular level of disease processes are available, it is very essential that drug designing be based on molecular mechanism of pathologic processes. Structure-based drug designing has made tremendous contributions in the field of cancer chemotherapy, drug resistant infections, neurological diseases, to mention a few. New drug discovery methods are furthered by developments in the technology especially computers, bioassay techniques and calibrated instruments. Computational structure-based drug designing opens the door to novel treatments in modern medicine.
Keywords
Designed drugs, discovery, drug, structure-based drug design
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