A serious drug interaction leading to spontaneous total hyphema

A 70 year-old diabetic man receiving anti-coagulant therapy (Warfarin) for pulmonary embolism secondary to factor V Leiden deficiency, presented to the hospital for chest pain. After initial evaluation, he was started on aspirin (300 mg) and clopidogrel (300 mg). Three days after he was discharged, he presented with preseptal cellulitis complicating left upper eyelid chalazion. Initially, he was treated with several anti-microbial agents used sequentially. Although, the cellulitis resolved, he developed total hyphema of the left eye. The complication seems to have resulted from a complex interaction amongst anti-microbial agents, Warfarin and anti-platelet agents.

Keywords
Anticoagulants/adverse effects, aspirin/adverse effects, clopidogrel/adverse effects, eye hemorrhage/etiology, hyphema/etiology, platelet aggregation inhibitors/adverse effects, Warfarin/adverse effects