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East and Central African Journal of Surgery
Association of Surgeons of East Africa and College of Surgeons of East Central and Southern Africa
ISSN: 1024-297X
EISSN: 1024-297X
Vol. 6, No. 2, 2001, pp. 29-31
Bioline Code: js01024
Full paper language: English
Document type: Research Article
Document available free of charge

East and Central African Journal of Surgery, Vol. 6, No. 2, 2001, pp. 29-31

 en Histopathological findings in post-inflammatory urethral strictures treated at Mulago hospital, Kampala, Uganda.
Karimbaev K, Kaggwa S, Kisalu M, Odida M.

Abstract

The predominant risk factor for recurrence of urethral stricture after surgical treatment is the extent of scarring and other related pathological findings in the affected segment of the urethra. In this study, 107 patients with post inflammatory urethral strictures aged between 23-79 years seen between 1996 and 1998 underwent a two-staged urethroplasty. During the first stage, incisional biopsies were taken from four areas namely the stricture itself, the segments proximal and distal to the stricture and the peri-urethral tissues surrounding the stricture. All the four biopsies for each patient were subjected to histological examination. The main histological finding was non-specific chronic inflammation and fibrosis. In the stricture part there was moderate diffuse chronic inflammation. In proximal segment, severe chronic inflammation with ulceration of stratified squamous epithelium and urinary pockets were the predominant histological findings. In the distal segment, mild chronic inflammation dominated. Lastly, in the periurethral tissues there was fibrosis interspersed with chronic mild inflammation.

Keywords
Histopathology, post-inflammatory, urethral strictures.

 
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