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East and Central African Journal of Surgery
Association of Surgeons of East Africa and College of Surgeons of East Central and Southern Africa
ISSN: 1024-297X
EISSN: 1024-297X
Vol. 18, No. 2, 2013, pp. 175-179
Bioline Code: js13047
Full paper language: English
Document type: Literature Review
Document available free of charge

East and Central African Journal of Surgery, Vol. 18, No. 2, 2013, pp. 175-179

 en Oncogenic osteomalacia: a case report and review of the literarture
Sayed, W.; Salah, M. B.; Chenguel, Z.; Raboudi, T.; Zoghalami, M. & M’Barek, M.

Abstract

Oncogenic osteomalacia is a rare paraneoplastic syndrome characterized by severe hypophosphoremia due to renal phosphate wasting and osteomalacia clinically near to hereditary hypophosphoremic rickets. This disorder is induced by a benign tumor which belongs to the group of « phosphaturic mesenchymal tumor mixed connective tissue variant » secreting phosphaturic factors. We report the case of a 54-year old man who presented with diffuse bone pain and bilateral hip pain evolving for 3 years. Physical examination revealed a subcutaneous tumor of the left flank. A radiographic skeletal survey showed signs of osteomalacia with an overall « washed-out » appearance of the bone, cuneiform aspect of dorsolombar vertebral bodies and bilateral fracture of femoral necks. Serum Fibroblast Growth Factor 23 concentration was high. The patient had total bilateral hips arthroplasty and surgical removal of the tumor of the flank was performed. There was rapid improvement and the laboratory values returned to normal.

Keywords
Oncogenic; Osteomalacia; Mesenchymal; Tumor; fibroblast; growth factor

 
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