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Challenges in Management of Pheochromocytoma at a Tertiary hospital in Northern Tanzania. A 21 Years Descriptive Retrospective Study.
Rugakingila, R.A. & Mteta, A.K.
Abstract
Background:
Pheochromocytomas are rare catecholamine-secreting
tumors that arise
from chromaffin tissue within the adrenal medulla and extra adrenal sites
(paraganglioma). Due to excess secretion of catecholamines, these tumors often cause
debilitating symptoms ending to death if actions are not taken. Management requires competent
physician, surgeons and anesthesiologists.
The main objective the study focused on pattern of
presentation and treatment challenges
of pheochromocytoma patients over a period of 21 years (1992- 2012)
Methods:
This was a retrospective study on patients underwent adrenelectomy at KCMC
Urology Institute during the course of 21 years and
histologically confirmed cases of
pheochromocytoma were enrolled. A structured data collection sheet was designed with
parameters of demographic data, disease presentation, investigations done, tumor
localization, surgical technique and follow up, in
a course of overseeing the challenges in
each step of management.
Results:
A total of 13 patients were included in this study, median age of participants was
25 years. M:F 6:7. Majority of patients presented with clinical features related to episodic
elevation of catecholamines. Localization of the tumor was done with ultrasonography,
Computer Tomography scan and upon surgical exploration.12 cases were found to have
right side tumor and 1 case was on the left. All cases were operated using the Chevron
incision as the main surgical approach.12 patients
got symptoms cured at the first 3 month
visit. One died in the ward.
Conclusion:
Upon a study Pheochromocytoma showed to be a rare condition. Despite the
challenges occurred in managing all the cases, surgery has cured in 99% of all patients
operated. Radiological investigation was able to localize the tumor in 100% of the patients.
Keywords
Pheochromocytoma; challenges; management
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