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A Two- year review of Colorectal Cancer at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia
Zemenfes, D. & Kotisso, B.
Abstract
Background:
Colorectal Cancer is the third most common cause of admission and death in
the West; and till recently it was thought to be an uncommon disease in Africa and Asia.
Although data from Ethiopia is unavailable, a recent report from Global cancer statistics
center shows an increasing incidence in the sub-Saharan Africa which is also our
observation. The objective of this study was to assess the hospital prevalence, common
presenting symptoms, common presenting signs, site, stage and histology of colorectal
cancer.
Methods:
A retrospective cross-sectional study design, by reviewing of patient records
collected from 2010 to 2011was used. Patient card numbers with colorectal and anal
cancer were retrieved from registry log book in the department of surgery. Individual
patient card was retrieved from the hospital record office. A total of 120 out of 142 patient
cards were included in the study. Data were entered using epi-data, version 3.0 and was
analyzed using SPSS for windows version 21, and descriptive data analysis using frequency
was made to answer the research question.
Results:
The mean age of the study subjects was 47 ± 16 years, ranging between 18 and 83
years. A third was below the age of 40 years, 58% were men, nearly half came from Addis
Ababa, and 20% presented as an emergency. Study subjects presented with rectal bleeding
(63.0%), abdominal pain (54.3%), weight loss (44.9%), tenesmus (39.4%), change in bowel
habit (48.0%) and symptoms of obstruction (17.3%). The study revealed mass on Digital
Rectal Examination in 50%, anemia in 24.4%, abdominal mass in 22.8% and signs of
obstruction among 11.8% of patients. The common sites of cancer were the rectum in
48.3% of cases followed by caecum (12.5%), sigmoid colon (11.5%) and recto-sigmoid
junction (10.8%). More than half of the study subjects had stage III to IV disease. More than
94% of the patients had histologically proven adenocarcinoma. Thirty four percent of the
cases had either inoperable or unresectable tumor indicative of delayed presentation. The
hospital mortality was 8.0%.
Recommendation:
Colorectal Cancer is a problem of significant magnitude and as the
outcome of treatment depends largely on the early detection of cases a detailed research
should be done to see the factors which hamper early detection and referral of cases to the
tertiary health facilities where multidisciplinary management is available.
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