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Indian Journal of Medical Microbiology
Medknow Publications on behalf of Indian Association of Medical Microbiology
ISSN: 0255-0857
EISSN: 0255-0857
Vol. 26, No. 1, 2008, pp. 50-53
Bioline Code: mb08010
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Medical Microbiology, Vol. 26, No. 1, 2008, pp. 50-53

 en High level ciprofloxacin resistance in Salmonella enterica check for this species in other resources isolated from blood
Raveendran, R.; Wattal, C.; Sharma, A.; Oberoi, J.K.; Prasad, K.J. & Datta, S.

Abstract

Purpose: Over the last few years, resistance to ciprofloxacin in Salmonella enterica check for this species in other resources has become a global concern. The present study was undertaken to find out the susceptibility pattern of Salmonella enterica isolates in our hospital.
Methods: Blood cultures were done using BacT/ALERT 3D system. The antimicrobial susceptibility testing was carried out by the Kirby-Bauer disc diffusion method using CLSI breakpoints. Minimum inhibitory concentration was determined for ciprofloxacin-resistant strains using E-test and Vitek-1 automated system.
Results: A total of 25,953 samples of blood culture yielded 431 Salmonella enterica serotype Typhi and 198 serotype Paratyphi A isolates. Twenty-two isolates of serotype Typhi were resistant to ciprofloxacin, while two isolates of Typhi and two Paratyphi A were intermediately susceptible to ciprofloxacin. Ciprofloxacin resistance is 5.6% (24 isolates) among Salmonella enterica serotype Typhi. Ampicillin, chloramphenicol and co-trimoxazole resistance in Salmonella enterica serotype Typhi appears to have decreased to 14.9% (64/431) in comparison to the 27% (55/205) during 2003. All isolates were sensitive to ceftriaxone.
Conclusions: Ciprofloxacin can no longer be considered as the drug of choice in treating Salmonella infections. While first-line antimicrobials may still have a role to play in the treatment of enteric fever, ceftriaxone remains the sole defence against ciprofloxacin-resistant Salmonella infections.

Keywords
Ciprofloxacin resistance, enteric fever, MIC, Salmonella enterica

 
© Copyright 2008 Indian Journal of Medical Microbiology.
Alternative site location: http://www.ijmm.org

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