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Indian Journal of Medical Microbiology
Medknow Publications on behalf of Indian Association of Medical Microbiology
ISSN: 0255-0857
EISSN: 0255-0857
Vol. 26, No. 2, 2008, pp. 158-159
Bioline Code: mb08045
Full paper language: English
Document type: Short Communication
Document available free of charge

Indian Journal of Medical Microbiology, Vol. 26, No. 2, 2008, pp. 158-159

 en Identification of weak points prone for mutation in ferredoxin of Trichomonas vaginalis check for this species in other resources
Wiwanitkit, V

Abstract

Trichomonas vaginalis check for this species in other resources , the causative agent for human trichomoniasis, is a problematic sexually transmitted disease mainly in women. At present, metronidazole-resistant trichomoniasis is an infrequent but challenging problem with no universally successful treatment. Genetic mutation is believed to be an important factor leading to increasing drug resistance. Understanding the mutation status will help to design accurate strategies of therapy against mutant strains of T. vaginalis . The author performed a bioinformatic analysis to determine positions that tend to comply peptide motifs in the amino acid sequence of ferridoxin of T. vaginalis . Based on this study, the weak linkages in the studied protein can be identified and can be useful information for prediction of possible new mutations that can lead to drug resistance. In addition, the results from this study can be good information for further research on the diagnosis for mutants and new effective drug development.

Keywords
Ferridoxin, mutation, Trichomonas vaginalis

 
© Copyright 2008 Indian Journal of Medical Microbiology.
Alternative site location: http://www.ijmm.org

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