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Indian Journal of Medical Microbiology
Medknow Publications on behalf of Indian Association of Medical Microbiology
ISSN: 0255-0857 EISSN: 0255-0857
Vol. 27, No. 4, 2009, pp. 351-353
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Bioline Code: mb09097
Full paper language: English
Document type: Short Communication
Document available free of charge
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Indian Journal of Medical Microbiology, Vol. 27, No. 4, 2009, pp. 351-353
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Oral fluid, a substitute for serum to monitor measles IgG antibody?
Goyal, A.; Shaikh, N. J.; Kinikar, A. A. & Wairagkar, N. S.
Abstract
We have analyzed the suitability and potential of Oral Fluid (OF) to substitute serum in estimating measles IgG antibodies, during community surveys, by comparing the Optical Density (OD) of measles IgG antibodies in OF and serum of 100 apparently asymptomatic children. IgG antibody status was determined using commercially available - Measles IgG Capture ELISA. Sensitivity 89.5%, specificity 90.6% Concordance of 89%, coefficient of correlation r is equal to 0.97 (Karl Pearson′s) and rho is equal to 0.86 (Spearman′s), was found between OD value of OF and serum. The study emphasizes the potential of OF to surrogate serum in estimating Measles IgG antibody among children. The OF collection is advantageous over blood as it is painless. It is suitable for non-technical staff, easy to transport and less bio-hazardous.
Keywords
Measles IgG antibody, Optical density, Oral fluid
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© Copyright 2009 Indian Journal of Medical Microbiology. Alternative site location: http://www.ijmm.org
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