In this study,
in vitro activity of tigecycline (TIG) and ertapenem (ERT) against clinical isolates of
Brucella melitensis
and the effect of different media on
in vitro test results were investigated. The
in vitro effects of TIG and ERT to 38
B. melitensis isolates were comparatively investigated in brucella agar and 5% sheep blood agar. MIC value of ERT was 0.032 μg/mL in 23 of 38 and 20 of 38 isolates on blood and brucella agar, respectively. Minimum inhibitory concentration values of TIG were substantially different ranging between 0.064-0.25 μg/mL on blood agar. However, MIC values of TIG were similar on brucella agar with 0.25 μg/mL in 15 of 38 isolates and 0.5 μg/mL in 10 of 38 isolates. In conclusion, although ERT and TIG were effective against
B. melitensis isolates
in vitro, further studies are needed in order to determine the use of these novel drugs in treatment of brucellosis.
