Indian Journal of Medical Microbiology
Medknow Publications on behalf of Indian Association of Medical Microbiology
Vol. 29, No. 1, 2011, pp. 19-21
Bioline Code: mb11005
Full paper language: English
Document type: Research Article
Document available free of charge
Indian Journal of Medical Microbiology, Vol. 29, No. 1, 2011, pp. 19-21
© Copyright 2011 Indian Journal of Medical Microbiology.
BinaxNOW® - An immunochromatographic test for the diagnosis of human influenza viruses: Comparison with viral culture and polymerase chain reaction|
Bhattacharya, S. & Osman, H.
Purpose: A rapid test for influenza viruses (Binax NOW® ) was evaluated.
Materials and Methods: In season-1, 35 respiratory samples were tested retrospectively; in season-2, 45 samples were tested prospectively [gold-standard: viral culture in season-1, culture+ reverse transcriptase-polymerase chain reaction (RT-PCR) in season-2].
Results: Sensitivity for Binax for influenza A was 59.3 and 0% in season-1 and -2, respectively. Sensitivity was low for influenza B (33.3% in season-1, 26.1% in season-2). Samples having low viral load were more likely to have a negative Binax test. Specificity of Binax was high (100 and 94.7% with influenza A and B, respectively).
Conclusion: Sensitivity information provided in the kit insert does not always reflect post licensure performance in clinical settings.
Influenza, rapid antigen test, sensitivity
Alternative site location: http://www.ijmm.org