search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 4, No. 3, 2001, pp. 111-113
Bioline Code: md01061
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 4, No. 3, 2001, pp. 111-113

 en EFFECT OF MAGNESIUM SUPPLEMENTATION ON PLASMA GLUCOSE IN PATIENTS WITH DIABETES MELLITUS
MELUDU S. C AND ADENIYI F. A. A

Abstract

Magnesium depletion and/or deficiency are known feature of diabetes mellitus, and could lead to increased insulin resistance and diabetic complications. This study therefore looked at the potential benefit of magnesium administration on the management of diabetic mellitus. Twelve apparently healthy and 6 non-insulin dependent diabetic (NIDDM) subjects received 15mmol (360 mg) elemental magnesium as NUG2 (Meram Laboratories, France) in 500 ml of 0.9% saline intravenously over four hours. Blood samples were collected at baseline and at hourly intervals. The diabetic subjects had lower ionized (0.41±0.03 vs 0.48±0.01 mmoIAL; P< 0.05) and total (0.73±0.04 vs 0.88±0.02 mmol/L; P< 0.05) plasma magnesium concentrations than the non-diabetic subjects, reflecting a depletion of body magnesium. The administration of magnesium led to a significant increase in ionized and total plasma magnesium in both non-diabetic and diabetic subjects. Similarly, plasma glucose and insulin were significantly decreased, and homeostasis model assessment showed an increase in insulin sensitivity in diabetic subjects. In established cases of magnesium depletion and/or deficiency in diabetes mellitus, magnesium supplementation could be of great benefit in diabetic management.

Keywords
Magnesium depletion - Magnesium administration - Diabetes mellitus - Insulin resistance

 
© Copyright 2001 - Ibadan Biomedical Communications Group

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2017, Site last up-dated on 16-Oct-2017.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil