search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 4, No. 3, 2001, pp. 123-126
Bioline Code: md01064
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 4, No. 3, 2001, pp. 123-126

 en EFFECT OF ADRENALINE ON GLUCOSE UPTAKE BY THE CANINE LARGE BOWEL
ALADA A.R.A, FAGBOHUN, T. D. AND OYEBOLAD.D. O.

Abstract

The effect of adrenaline on the glucose uptake by the large intestine was studied on a fasted, anaesthetized dog. A vein draining a segment of the colon was cannulated for blood flow measurement and blood samples were obtained for measurement of glucose content of the arterial and venous blood from the colonic segment. Glucose uptake was calculated as the product of colonic blood flow and arterio-venous glucose difference {(A-V) glucose}. When adrenaline (5μg/kg) was injected, glucose uptake by the colon increased by about 150%. This increase is much less than increases of 400% and 700% observed in upper jejunium and terminal ileum respectively in previous studies. However, the resting glucose uptake of (28.28 ± 20mg/min) of the colon is higher than that of the small intestine (17.77 ± 1.56 mg/min). We suggest from our studies that lower glucose uptake in the colon may well indicate a lower metabolic activity in the colon. From the results we concluded that the colon is involved in glucose homeostasis and that the colonic increase in glucose uptake in response to adrenaline is mediated by alpha and beta adrenergic receptors.

Keywords
Adrenaline, glucose uptake, colon, dog, adrenergic receptors

 
© Copyright 2001 - Ibadan Biomedical Communications Group

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2017, Site last up-dated on 05-Dec-2017.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil