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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 4, No. 3, 2001, pp. 127-129
Bioline Code: md01065
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 4, No. 3, 2001, pp. 127-129

 en RELAXANT EFFECTS OF THE AQUEOUS LEAF EXTRACT OF Cassia occidentials check for this species in other resources ON RAT AORTIC RINGS
AJAGBONNA O.P.. MOJIMINIYI F.B.O AND SOFOLA O.A

Abstract

The relaxant effects of an aqueous extract of the leaf of plant cassia occidentalis (C.O.) were investigated in rat aortic rings with or without intact endothelium. The extract inhibited contraction elicited by noradrenaline (NA) and Potassium Chloride (KCI) dose dependently. It also relaxed aortic rings precontracted with 10-7 M NA and 50m M KCI. This relaxation did not require the presence of an intact vascular endothelium and was not affected by indomethacin (Prostacylin inhibitor) and methylene blue.

Keywords
Cassia occidentials; Rat aorta; Vasodilatation, Vascular endothelium.

 
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