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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 4, No. 3, 2001, pp. 131-133
Bioline Code: md01066
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 4, No. 3, 2001, pp. 131-133

 en ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF LEAF EXTRACTS OF Landolphia owariensis check for this species in other resources
OWOYELE B.V, OLALEYE S.B, OKE J.M. AND ELEGBE R.A.

Abstract

The aqueous, methanol and chloroform extracts of Landolphia owariensis check for this species in other resources leaves (AELO, MELO & CELO respectively) was investigated for anti-inflammatory and analgesic activities. All the extracts (100mg/kg each) were found to significantly (P<0.05) inhibit paw edema induced by carrageenan in rats and the nociception induced by Tail immersion in hot water (50.0 ± 1.0°C) and acetic acid. The methanol extract produced the highest paw edema inhibition while in thermally induced nociception both the MELO and CELO show high and comparable analgesic activity with acetylsalicylic acid (150mg/kg). However in chemically induced pain (acetic acid) MELO produced the highest and comparable analgesic activity to acetylsalicylic acid (150mg/kg). We therefore conclude, that apart from the folklore uses of L. Owariensis leaves as antimalarial agents, the various extracts of the plant also possess anti-inflammatory and analgesic activities. Phytochemical analysis showed that the methanollic extract of L. owerensis contain some secondary metabolites namely: alkaloids and some polyphenolic compounds. Also, this extract exhibits some anti-oxidative activities.

Keywords
Landolphia owariensis - analgesic - anti-inflammatory-rats

 
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