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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 6, No. 2, 2003, pp. 73-77
Bioline Code: md03014
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 6, No. 2, 2003, pp. 73-77

 en TETANUS TOXOID ANTIBODY LEVEL IN ASYMPTOMATIC PLASMODIUM FALCIPARUM check for this species in other resources MALARIA PARASITEAMIC PREGNANT WOMEN.
ONYENEKWE C.C, MELUDU S.C, ARINOLA O.G., SALIMONU L.S.

Abstract

The present study was designed to investigate if the presence of asymptomatic malaria parasiteamia in pregnant women will compromise their ability to respond to full dose of tetanus toxoid immunization during their antenatal clinic visits. Hence, 90 apparently healthy pregnant women who had completed the tetanus toxoid immunization during the current pregnancy were recruited at the antenatal clinic and were divided into two groups based on the antenatal record of malaria paras during the immunization period. Sixty (66.7%) of the pregnant women were seroreactive for Plasmodium falciparum check for this species in other resources histidine rich protein- (HRP)-2 while 30 (33.3%) were seronegative for Plasmodium falciparum HRP-2. The malaria parasite density range for the seroreactive group was between 322 and 1045 parasites per ml of blood. The blood concentration of Tetanus toxoid antibody response in both groups of seroreactive and seronegative HRP-2 pregnant women did not show any significant difference in tetanus toxoid antibody response (p>O.2). This result showed that the presence of asymptomatic IPlasmodium falciparum malaria parasiteamia in the pregnant women during the immunization schedule did not compromise the ability to respond to tetanus toxoid immunization. Hence asymptomatic malaria may not contribute to the prevalence of neonatal tetanus in Nigeria , however, there is need to treat these pregnant women for asymptomatic malaria when detected in order to reduce the burden of malaria on them.

Keywords
Tetanus toxoid, asymptomatic malaria, specific antibody, pregnant women

 
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