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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 6, No. 2, 2003, pp. 85-90
Bioline Code: md03016
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 6, No. 2, 2003, pp. 85-90

 en ANTIMICROBIAL ACTIVITIES OF TWO NIGERIAN EDIBLE MACRO-FUNGI- LYCOPERDON PUSILUM check for this species in other resources (Bat. Ex) AND LYCOPERDON GIGANTEUM check for this species in other resources (Pers.)


Two edible Nigerian macro-fungi - Lycoperdon pusilum check for this species in other resources and Lycoperdon giganteum check for this species in other resources were assayed in-vitro for their antimicrobial activities using water, methanol and ethanol as extractive solvents. Generally, the extracts were selectively active on few clinical pathogenic microorganisms. Ethanol was the best extractive solvent followed in order by methanol and water (P ≤ 0.05). The best inhibitory zone (24.0mm) was recorded in ethanol extract of L. giganteum with inhibitory zone of 21.0mm. The least inhibitory zone, (4.0mm) was recorded with the aqueous extract of L. pusilum against Proteus vulgaris. The best antifungal activity (17.0mm), was recorded in L. giganteum extract against Microsporum boulardii check for this species in other resources . The minimum inhibitory concentration (MIC) for the ethanolic extract was between 0.75 and 4.0mg/ml for bacteria, and between 9.00 and 13.75mg/ml for fungi. The extracts were found to be stable at temperatures up to 50 °C. As the temperature was increased from 60 to 100 °C, there was a significant decrease in stability of the extract. The implications of these observations are discussed.

Antimicrobial activities, macro-fungi, extractive solvents, Inhibitory zone

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