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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 6, No. 2, 2003, pp. 91-94
Bioline Code: md03017
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 6, No. 2, 2003, pp. 91-94

 en THE EFFECT OF A FIXED NON-MINERAL OIL ON THE ANTIBACTERIAL ACTIVITY OF AMPICILLIN TRIHYDRATE AGAINST RESISTANT CLINICAL STRAINS OF STAPHYLOCOCCUS AUREUS check for this species in other resources .
O.E ADELEKE and J.O. OLAITAN

Abstract

The effect of King's Vegetable oil, a fixed non-mineral oil, on the antibacterial activity of ampicillin trihydrate, a water- insoluble form of ampicillin, was investigated against resistant clinical strains of Staphylococcus aureus check for this species in other resources . In the agar-diffusion method employed, 40% of the resistant clinical strains tested showed sensitivity to different oil-dispersed concentrations of ampicillin trihydrate, which ranged from 0.06μg/ml to 1.25μg/ml. The resistant strains were among the clinical strains detected with Beta-lactamase. This finding is presented as a preliminary report on the potentiality of employing an oil medium to effect a "cure" of antibiotic resistance in staphylococci besides the use of acridine dyes, ethidium bromide, ultraviolet radiation and other measures.

Keywords
King's vegetable oil, ampicillin trihydrate, staphylococcus aureus

 
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