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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 6, No. 3, 2003, pp. 146-147
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Bioline Code: md03057
Full paper language: English
Document type: Research Article
Document available free of charge
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African Journal of Biomedical Research, Vol. 6, No. 3, 2003, pp. 146-147
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Short Communication - EFFECT OF AQUEOUS LEAF EXTRACT OF SOLANUM AETHIOPICUM ON ISOLATED GUINEA PIG ILEUM
SABA, A. B, DINA, O. A, ADEDAPO, A.A AND AKHIROMEN, I.O
Abstract
Pharmacological reactivity of guinea pig ileum to aqueous extract of Solanum aethiocpicum was determined in vitro. Extract of the vegetable contracted the isolated ileum in a dose dependent fashion. These contractions were inhibited by mepyramine (5x10 -5 M) cimetidine (5 x 10 -5 M )and atropine (5x10 -5 M) inferring that the stimulatory effects were modulated by H1 and H2 (histaminergic and muscarinic (cholinergic) receptors. The mechanism of action of the laxative effect of Solanum aethiopicum was observed to be more than the bulk forming property of indigestible cellulose contained in vegetables generally.
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