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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 7, No. 1, 2004, pp. 19-21
Bioline Code: md04005
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 7, No. 1, 2004, pp. 19-21

 en ACUTE TOXICITY STUDY OF METHANOLIC EXTRACT OF ASPARAGUS PUBESCENS ROOT IN RATS
PAUL A. NWAFOR T. W. JACKS AND O.O. LONGE

Abstract

The acute toxicity study of methanolic extract of Asparagus pubescens check for this species in other resources root was studied on rats. The indices of the study were the liver enzymes (transaminases), cholesterol, creatinine and urea serum levels as well as the ionic analysis. Both alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) showed a significant (p<0.01-0.001) non dose-dependent increases in serum levels. There was a dose-dependent increase in cholesterol serum level (p+) and Hydrogen carbonate (HC03-) ions showed non-discriminatory rise relative to control while converse was correct for Sodium (Na+) and Chloride (Cl-) ions. The physical signs of toxicity ranged from decreased motor activity, loss of appetite to increased respiratory rate which was followed by restlessness, gasping and death. The effects may in part be due to its chemical (steroid) constituent.

Keywords
Asparagus pubescens, Acute toxicity, Methanolic extract, Rat

 
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