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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 7, No. 1, 2004, pp. 23-26
Bioline Code: md04006
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 7, No. 1, 2004, pp. 23-26

 en TOXICITY POTENTIALS OF CASSIA FISTULA FRUITS AS LAXATIVE WITH REFERENCE TO SENNA
M. A. AKANMU; E. O. IWALEWA; A. A. ELUJOBA AND K. A. ADELUSOLA

Abstract

The aqueous extract of the pods of Cassia fistula check for this species in other resources Linn (Leguminosae - Caesalpinoideae), cultivated in Ile-Ife, Nigeria were investigated for pharmacological and toxicological properties. The in-vitro effect of Cassia fistula infusion on isolated guinea-pig ileum was examined. The acute and sub-chronic toxicity of the infusion of C. fistula and Cassia acutifolia check for this species in other resources Del. Pod-(Senokot tablet) as the reference drug were also determined. The results obtained for C .fistula infusion when compared with senokot tablet showed that the infusion of Cassia fistula pods possessed very low levels of toxicity, having the LD50 of 6600mg/kg and also without any pathological effects on the organs examined microscopically. It is therefore concluded from the study that C. fistula pod infusion could be safely utilized as laxative drugs and as a substitute for the official Senna.

Keywords
Cassia fistula pods, Senokot tablet, acute and sub-chronic toxicities, gastrointestinal

 
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