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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 7, No. 3, 2004, pp. 129-132
Bioline Code: md04028
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 7, No. 3, 2004, pp. 129-132

 en EVALUATION OF THE ANTI-OXIDANT AND ANTI-ANGIOGENIC EFFECTS OF SPHENOCENTRUM JOLLYANUM PIERRE
NIA R, PAPER D.H, ESSIEN E.E, IYADI K.C, BASSEY A.I.L, ANTAI A.B; FRANZ, G

Abstract

The methanol extracts of Sphenocentrum Jollyanum organs were assessed for their anti-oxidant and anti-angiogenic activities using DPPH and CAM assays respectively. The results indicated the stem bark as the most active organ with an IC50 of 1.80 ± 0.25 and 1.00 ± 0.20 score (at 500 μg/pellet) on DDPH and anti-angiogenesis assays respectively. Further fractionation of the stem bark revealed the chloroform fraction to have the highest IC50 1.54 ± 0.15 and the most important score on anti-angiogenesis assay with 1.3 ± 0.10 at 250 μg/pellet when serially diluted between 250 and 36.2 μg/pellet. Moreover, the effects were found to be dose-dependent. These results bring to the fore the need for further studies towards confirming the anti-oxidant and anti-angiogenic potentials of the plant as well as identifying and characterizing the active principles for drug development.

Keywords
Anti-oxidant, anti-angiogenic, CAM, Sphenocentrum jollyanum, Menispermaceae.

 
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