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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 8, No. 1, 2005, pp. 59-61
Bioline Code: md05010
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 8, No. 1, 2005, pp. 59-61

 en Short report - Inhibitory Effects of Musanga cecropioides check for this species in other resources on Noradrenaline and Potassium-Induced Contractions in Rat Thoracic Aorta
PETER I. AZIBA

Abstract

The pharmacological effects of Musanga cecropioides check for this species in other resources on rat thoracic aorta were examined in high K+ medium (55mM), Ca2+ 3mM) induced vasoconstriction was inhibited by Musanga cecropioides in a concentration-dependent manner. The tonic contractions elicited by KCI 55mM were relaxed by Musanga and were more marked in 0.45mM Ca2+ than 1.8mM Ca2+ medium. NA -induced responses were antagonized non competitively by Musanga. NA- sustained contraction was relaxed, the relaxing effect of Musanga was not antagonized by indomethacin or methylene blue. It is concluded that Musanga relaxation of the rat aorta does not involve cyclo-oxygenase, nor cAMP pathway, but unique, unlike those of known classical vasodilators.

Keywords
Musanga cecropioides, contraction, inhibition, Potassium, thoracic aorta

 
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