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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 8, No. 2, 2005, pp. 95-99
Bioline Code: md05017
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 8, No. 2, 2005, pp. 95-99

 en In vitro and In vivo evaluation of free radical scavenging potential of Cissus quadrangularis check for this species in other resources
Mallika Jainu and C.S. Shyamala Devi

Abstract

The present study was performed to evaluate the effect of the methanolic extract of Cissus quadrangularis check for this species in other resources (CQE) against free radical damage. The test extract exhibited significant inhibition in DPPH free radical formation, superoxide radical production and lipid peroxide production in erythrocytes. The activities of liver marker enzymes and antioxidant defense enzymes in rat liver homogenate were assessed in control and experimental animals. Carbon tetrachloride (CCl4) caused a significant increase in aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT), alkaline phosphatase (ALP), and decrease in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH), which was reverted by CQE pretreatment. The results obtained suggest that CQE showed inhibition of lipid peroxidation, free radical production and increase in antioxidant enzymes activities, which reveal its antioxidant property. It can be concluded that the free radical scavenging activity of the plant extract may be responsible for the therapeutic action against tissue damage.

Keywords
Free radicals, In vitro, Cissus quadrangularis, CCl4, Antioxidant activity

 
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