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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 8, No. 2, 2005, pp. 119-121
Bioline Code: md05021
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 8, No. 2, 2005, pp. 119-121

 en Short Communication - Anti-Stress Potential of Aqueous Seed Extract of Aframomum Melegueta check for this species in other resources
Umukoro, S and Ashorobi, R.B

Abstract

This study presents the results of the phytochemical screening and anti-stress potential of aqueous seed extract of Aframomum melegueta check for this species in other resources (MS) in mice. The forced swimming endurance test was utilized as a model for the evaluation of the anti-stress property of MS. The phytochemical tests showed the presence of alkaloids, reducing sugars, flavoniods, phenols and glycosides in the extract of A.melegueta. In the forced swimming test, MS (50-200 mg/kg, i.p) significantly prolonged the duration of immobility in a dose-related manner. The duration of immobility (s) was increased from 236.67±18.2 in the control group to 410 ±11.57 and 579 ±28.71 in groups pretreated with 100 and 200 mg/kg of MS respectively. The inability of the extract of this plant to reduce the duration of immobility, therefore suggests a lack of anti-stress property.

Keywords
Forced swimming test, immobility, Aframomum melegueta, a-methyldopa, amphetamine

 
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