African Journal of Biomedical Research
Ibadan Biomedical Communications Group
Vol. 8, No. 2, 2005, pp. 123-125
Bioline Code: md05022
Full paper language: English
Document type: Research Article
Document available free of charge
African Journal of Biomedical Research, Vol. 8, No. 2, 2005, pp. 123-125
© Copyright 2005 - Ibadan Biomedical Communications Group
Short Communication - Acute Restraint Stress Induces Hyperalgesia via Non-Adrenergic Mechanisms in Rats|
OYADEYI A. S, AJAO F. O, IBIRONKE G.F, AFOLABI A.O
Analgesia or hyperalgesia has been reported to occur in animals under different stress conditions. this study examined the effect of acute restraint stress on nociception in rats. Acute restraint stress produced a time-dependant decrease in pain threshold; this hyperalgesia was not affected by prior administration of adrenergic blockers suggesting the non-involvement of adrenergic mechanisms. The hyperalgesia may however result from a change in the affective state of the animal and not from a change in sensory processing of noxious stimulus.
Stress, hyperalgesia, tail-flick test, sympathetic nervous system.