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Some Neuropharmacological Effects of the Methanolic Root Extract of Cissus Quadrangularis in Mice
Viswanatha Swamy A.H.M. Thippeswamy A.H.M, Manjula D.V. and Mahendra Kumar C.B
Abstract
In this study, some neuropharmacological effects of methnolic root extract of Cissus quadrangularis Linn. (CQ) belongs to family Vitaceae were studied in mice using various models. The CQ root extract significantly inhibited acetic acid-induced writhings and increased tail flick withdrawal response in mice. The effects of CQ on CNS were studied by using, spontaneous motor activity, exploratory behaviour, rota-rod performance and potentiation of pentobarbitone sleeping time in mice. Preliminary phytochemical evaluation and acute toxicity values were also carried out and LD50 was found to be 1000 mg/kg by i p route. The extract (50,100 and 200 mg/kg i. p.) produced reduction in spontaneous motor activity, exploratory behaviour and motor coordination and prolonged pentobarbitone sleeping time. Preliminary qualitative chemical studies indicated the presence of triterpenoids, flovonols, sapononis, and alkaloids in the extract. The results suggest that the methanolic root extract of CQ contains some active principles, which may be sedative in nature.
Keywords
Cissus quadrangularis; Sedation; Spontaneous motor activity, Exploratory Behaviour, Motor coordination, Pentobarbital sleeping time
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