Diphenyl Dimethyl Bicarboxylate as an Effective Treatment for Chemical-Induced Fatty Liver in Rats

To assess the protective effect of diphenyl dimethyl bicarboxylate (DDB) in carbon tetrachloride (CCl4) - induced fatty liver in male rats .Fatty liver was induced by single intraperitoneal ( IP ) CCl4 dose of 0.2mL /kg , treated group was given the same CCl4 dose , then given oral daily doses of DDB as 300 mg /kg body weight for 4 weeks . A control group , given saline orally was run against the other two groups . Each group consisted of 10 male Wistar albino rats. Liver weight ( in g ) , liver tissue contents of total protein ( TP) , total lipids (TL) , phospholipids (PL) , total cholesterol (TC) and triglycerides (TG) as mg / g wet tissue were investigated. CCl4 treatment significantly increased liver tissue weight , TL ,TC , TG , but decreased both TP and PL . DDB treatment after CCl4 intoxication , recovered these variables near normalcy. The study substantiates the protective action of DDB against CCl4 - induced fatty liver , through assessment of most tissue parameters known to be disrupted in fatty liver . The drug significantly decreased both liver weight ,TL ,TC ,TG and increased both PL and TP , so improved fat mobilization from chemical-induced fatty liver

Keywords
Fatty liver , rats , carbon tetrachloride , DDB , total protein , total lipids , total cholesterol , phospholipids , triglycerides