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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 9, No. 2, 2006, pp. 101-107
Bioline Code: md06018
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 9, No. 2, 2006, pp. 101-107

 en Neuropharmacological Effects of Aqueous Leaf Extract of Bryophyllum Pinnatum check for this species in other resources in Mice
Salahdeen H.M and Yemitan O.K

Abstract

Effects of aqueous leaf extracts of Bryophyllum Pinnatum check for this species in other resources (AEBP) on some neuropharmacological activities were studied in mice. The extract in dosages (50,100 and 200 mg/kg) was found to produce a profound decrease in exploratory activity in a dose-dependent manner. It also showed a marked sedative effect as evidenced by a significant reduction in gross behaviour and potentiation of pentobarbitone-induced sleeping time. It delayed onset in strychnine-and picrotoxin-induced convulsion (seizures) respectively with the protective effect being significantly higher in picrotoxin- than strychnine-induced convulsion. It also decreases the rate of picrotoxin-induced mortality in mice with LD50 of 641mg/kg. The totality of these effects showed that the extract possesses depressant action on the central nervous system

Keywords
Bryophyllum pinnatum, Neuropharmacology, exploration, anticonvulsant, muscle relaxant.

 
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