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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 9, No. 3, 2006, pp. 205-211
Bioline Code: md06033
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 9, No. 3, 2006, pp. 205-211

 en In-vitro Anti-Microbial and Brine-Shrimp Lethality Potential of the Leaves and Stem of Calotropis procera check for this species in other resources (Ait).
Oladimeji, H.O.; Nia, R. & Essien, E.E.

Abstract

Calotropis procera check for this species in other resources (Family, Asclepiadeae) is implicated in a variety of ethno-medicinal therapies ranging form oral, skin, gastro-intestinal to respiratory problems. The effects of this plant on the sensitivity of micro-organisms need verification and its potential for cytotoxicity needs to be investigated. Thus, the anti-microbial and brine–shrimp lethality studies on the leaves and stem were carried out. The crude ethanolic extract of the stem and its ethylacetate fraction elicited good antibacterial activity against clinical strains of Bacillus subtilis check for this species in other resources , Staphylococcus aureus but gave minimal activity against Escherichia coli check for this species in other resources , Klebsiella pneumoniae check for this species in other resources and Salmonella typhi check for this species in other resources but none against the fungal isolate; Candida albicans check for this species in other resources . The brine-shrimp lethality assay analyzed using the Finney probit method showed that the crude ethanolic extracts of the leaves and stem displayed LD50 values at 192 ppm and 182 ppm respectively. These findings indicate the potential of the plant as panacea for infectious diseases and also reveal a novel potential in the fight against tumors in man.

Keywords
Anti-microbial, extracts, fractions, brine-shrimp lethality, Calotropis procera

 
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