Toxic Effects of Non-Steroidal Anti-Inflammatory Agents in Rats|
Abatan, M.O.; Lateef I. & Taiwo V.O.
The toxicosis of some non-steroidal anti-inflammatory drugs, piroxicam, indomethacin, phenylbutazone, and aspirin, which occasionally are locally used in Nigeria as rodenticides have been evaluated in rats using changes in the serum biochemical and haematological parameters as indices of toxicity. In the study, no clinical symptoms were observed in all the treatment groups except in the group of animals exposed to indomethacin which showed decreased feed intake, sluggishness, diarrhoea and some mortality were also recorded in the group. On the serum biochemical parameters, indomethacin and piroxicam caused increases in the level of total bilirubin and decreases blood urea nitrogen. Aspirin, indomethacin, and phenylbutazone produced increases in serum aspartate aminotransferase and this increase is significant (P<0.05) with the group treated with indomethacin compared to the control group. Indomethacin also caused significant (P<0.05) increase in the level of serum alanine aminotransferase. None of the treatment groups produced significant changes in haematological parameters except that indomethacin produced significant increase (P<0.05) in the total white blood cell count. Histological studies revealed that indomethacin also caused mild periportal hepatic necrosis and kupffer cell proliferation. This study therefore shows that some non steroidal anti-inflammatory drugs may have adverse effects in rats. Indomethacin has the greater toxic effect on rodents and this may suggest why it is marketed in Nigeria as a rodenticide.
NSAID, toxicity, histopathology, rat