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Non-Enzymatic Antioxidants and Nutritional Profiles in Newly Diagnosed Pulmonary Tuberculosis Patients in Nigeria.
Akiibinu, M.O.; Arinola, O.G.; Ogunlewe, J.O. & Onih E.A
Abstract
The effects of pulmonary tuberculosis on nutritional and antioxidants status
was determined in thirty-one patients attending Chest Clinic, Oyo State
Hospital, Jericho, Ibadan Nigeria by assessing the levels of total protein,
albumin, globulin, total cholesterol, HDL cholesterol, LDL cholesterol, uric
acid, vitamin C, vitamin E and total antioxidants. Thirty-four members of staff
of State Hospital Adeoyo Ibadan, Nigeria were selected as controls. The mean
levels of total protein (7.13±1.06g/dl), albumin (3.27±0.7g/dl), total
cholesterol (100.7±23.6mg/dl), HDL cholesterol (28.6±7.2mg/dl), LDL
cholesterol (65.5±15.1mg/dl) and triglycerides (61.6±16.2mg/dl) were
significantly low while the level of globulin (3.9±0.84g/dl) was significantly
high in pulmonary tuberculosis patients when compared with controls (total
protein = 7.6±0.7g/dl; albumin = 4.2±0.48g/dl; total cholesterol =
163.2±40.1mg/dl; HDL cholesterol = 41.4±5.4mg/dl; LDL cholesterol =
107.8±27.5mg/dl; globulin= 3.4±0.6g/dl ). Levels of vitamin C
(18.5±1.6mg/l), vitamin E (6.9±1.7mg/l) and total antioxidant
(0.83±0.34mmol/l) were significantly lower while the level of uric acid
(5.2±2.1mg/dl) was significantly higher in patients with pulmonary
tuberculosis when compared with the controls (vitamin C = 23.1±2.3mg/l;
vitamin E = 12.5±1.6mg/l; total antioxidant = 1.65±0.26mmol/l; uric acid =
4.3±1.2mg/dl respectively). Significantly lower levels of antioxidants might
have been caused by endogenous uric acid production.
Keywords
Antioxidants, nutritional profiles, pulmonary, tuberculosis.
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