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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 10, No. 2, 2007, pp. 229 - 234
Bioline Code: md07032
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 10, No. 2, 2007, pp. 229 - 234

 en Safety, Efficacy and Tolerability of Meprasilm in the Treatment of Dyspepsia among Nigerians.
Otegbayo, J.A.; Adedapo, A.; Adedapo, K.S.; Akere, A.; Aje, A.O. & Igetei, R.

Abstract

A clinical trial was carried out to establish the tolerability, safety and efficacy of Meprasil brand of omeprazole among Nigerians with acid peptic disease using 20mg daily or 20mg bid of Meprasil. Forty patients were enrolled for the study and were asked to rate their abdominal pains pre-commencement of therapy using a scale of mild, moderate or severe. Serum alanine transaminase (ALT), urinalysis, electrolytes, creatinine and urea were carried out before and after treatment. Patients were then evaluated on days 0, 1, 3, 7, 14, and 28, thereafter monthly for 4 months for relief of symptoms and adverse drugs effect. Only 32 patients completed the study, 17 (Group I) and 15 (Group II).
fe, efficacious and well tolerated in amelioration of pain of acid peptic disorder among Nigerian patients.

Keywords
Meprasil, efficacy, tolerability, Dyspepsia, Nigerians

 
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