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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 11, No. 3, 2008, pp. 323-327
Bioline Code: md08045
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 11, No. 3, 2008, pp. 323-327

 en Effects of Methanolic Root Extract of Ledebouria ovaltifolia check for this species in other resources (Hyacithaneae) on Isolated Smooth Muscle Preparation in Rats
Aziba, Peter I.

Abstract

This study investigated the receptor effects of methanolic root extract of Ledebouria ovaltifolia check for this species in other resources on Acetylcholine and Potassium (K+) induced contractions in Rat stomach strip (RSS), Adrenaline and K+ (induce contractions) in rat vas deferens (RVD), and carbachol and K+ induced contractions in rat uterus (RUT). Effects of the root extract (1.27mg/mL) on acetylcholine (6.8x10-9 to 10.4x10-8 M) adrenaline 2x10-7M, carbachol (2x10-8M-1.6x10-7M), and K+ contractions were non competitive. Results of muscle contractility in zero-Ca2+containing 0.5mM EGTA varies in these tissues in this order RSS>RVD>RUT. It is concluded in this study, the inhibitory effect of the extract was non specific on muscarinic, adreneceptors nor depolarised membrane site. The effect of the extract was more marked on potassium (K+) than receptor mediated contractions.

Keywords
ledebouria Ovaltifolia, Extract, methanolic, smooth muscle contractions, rodents

 
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