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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 12, No. 3, 2009, pp. 199-207
Bioline Code: md09034
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 12, No. 3, 2009, pp. 199-207

 en Anti-Inflammatory and Analgesic Potential of Methanolic Extract of Emilia Sonchifolia check for this species in other resources (Compositae) Leaves in Rodents
Essien, G.E.; Nwidu, L.L. & Nwafor, P.A.

Abstract

Emilia sonchifolia check for this species in other resources (Lin)DC (compositae) has found various medicinal uses in folkloric medicine, as a cure for various ailment such as sore-throat, tonsillitis, styptic, vulnery, wounds healing, stomach ache, conjunctivitis, depurative, infantile tympanitis, anticonvulsants, bowel complaints and sores; aqueous extract is used to treat internal heat among pregnant women. The need to pharmacologically establish these claims stimulated this investigation of the plant. The LD50, preliminary phytochemical screening, anti-inflammatory and analgesic potentials of the methanolic extracts of Emilia sonchifolia check for this species in other resources (ES) were investigated in mice using carragenin, egg albumin, capsaicin-induced paw oedema, formalin-induced paw licking, acetic acid induced writhing and hot plate nociception in mice. The LD50 i.p. was calculated to be 2874.02mg/kg; phytochemical screening revealed the presence of terpines, flavonoids, tannins, saponins and alkaloids. The extract (287.4, 574.8, 862.2, ASA (100mg/kg) and 574.8 + ASA (mg/kg) (i.p.) produced a dose dependent (p <0.05-0.001) inhibition carragenin, egg-albumin, capsaicin, formalin-induced paw licking, acetic acid-induced writhing and hot plate nociception in mice. Preliminary phytochemical screening revealed the presence of flavonoids, tannins and alkaloids. Results from this study show that ES may be useful as anti-inflammatory and analgesic agent.

Keywords
Emilia sonchifolia, anti-inflammatory, analgesic, Acute toxicity, Phytochemical screening.

 
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