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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 13, No. 1, 2010, pp. 61-68
Bioline Code: md10010
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 13, No. 1, 2010, pp. 61-68

 en In-vitro Antimicrobial Activities of Methanol Extracts of Zanthoxylum xanthoxyloides check for this species in other resources and Pseudocedrela kotschyi check for this species in other resources
Adeniyi, C.B.A.; Odumosu, B.T; Ayelaagbe, O.O & Kolude, B

Abstract

The antimicrobial activities of two Nigerian medicinal plant commonly used as chewing sticks Zanthoxylum xanthoxyloides check for this species in other resources and Pseudocedrela kotschyi check for this species in other resources antimicrobial activities were investigated against 7clinical strains of Streptococcus mutans check for this species in other resources , Staphylococcus aureus check for this species in other resources ATCC 29213, Candida albicans check for this species in other resources , Candida tropicalis check for this species in other resources and Candida krusei check for this species in other resources ATCC 6825. The antibacterial and antifungal activities of the extracts were determined using the agar well diffusion and surface plate method respectively. Zanthoxylum xanthoxyloides, was active against all the isolates especially on the bacteria with a MIC and MBC of 12.5mg/mL and 25mg/mL respectively. Pseudocedrela kotschyi showed no activity on all the tested isolates except on C. krusei ATCC 6825 with a MIC of 6.25mg/mL. . Streptococcus mutans, S. aureus ATCC 29213 and C. albicans were completely killed within the time period of 4hrs by Z. xanthoxyloides extracts in time kill study. A good correlation was found between the killing curves and the MIC of Z. xanthoxyloides against the tested isolates. Phytochemical screening revealed the presence of alkaloids, tannins, flavonoids, saponins and traces of terpenoids. Ability of Z. xanthoxyloides crude extracts to inhibit the growth of the bacteria and fungi used in this study is an indication that the plant can be used as a source for antimicrobial agent in the development and formulation of toothpaste, thus justifying the use of the plant in locally as chewing sticks..

 
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