The effect of ethanolic extract of Smilax krausiana
(Smilaceae) leaf was investigated for its analgesic and antiinflammatory
activities in mice. The extract significantly (p<0.01-0.001) inhibited in a dose – dependent fashion algesia
(nociception) induced by acetic acid, formalin and hot plate. It also reduced in dose-related manner inflammation induced by
fresh egg albumin, carrageenin and capsaicin. These inhibitions were statistically significant (p<0.01 – 0.001). Though the
mechanism of action of the extract is not fully elucidated, it may in part involve suppression of capillary permeability through
neurogenic and non-neurogenic pathways as well as its narcotic potential. The extract’s inhibition of all the models
investigated in a non-specific manner supports the folkloric use of the plant.