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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 13, No. 2, 2010, pp. 149-152
Bioline Code: md10024
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 13, No. 2, 2010, pp. 149-152

 en Analgesic Activity of the Methanolic Leaf Extract of Jatropha Curcas check for this species in other resources (Linn)
Omeh, Yusuf S & Ezeja, Maxwell.I.

Abstract

This study evaluated the analgesic activity of the metabolic leaf extract of Jatropha Curcas check for this species in other resources (Linn) in vivo using analgesic models viz: Hot plate method in mice, tail flick or immersion method in rat and acetic acid-induced writhing reflex model in mice. In all the models, acetylsalicylic acid (ASA) was used as the reference drug. In the hot plate and tail flick models, the oral administration of J. curcas extract at the doses of 100, 200 and 400 mg/kg and the reference drug ASA (400 mg/kg) showed potent analgesic effect by significantly (P<0.001) increasing the pain reaction time dose dependently in mice and rats. Also the reference drug and the extract of J. curcas significantly (P<0.0001) decreased the number of the abodominal contortions in the acetic acid-induced writing reflex in mice and increased the percentage protection in a dose dependent manner. In conclusion, this study indicates that the methanolic leaf extract of Jatropha curcas has significant analgesic properties and may be acting through both peripheral and central pain mechanisms.

Keywords
Analgesic, Jathropha curcas, hot plate, tail flick, writhing reflex, acetylsalicylic acid.

 
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