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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 14, No. 1, 2011, pp. 27-34
Bioline Code: md11005
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 14, No. 1, 2011, pp. 27-34

 en Testosterone Enhances the Early Onset and Promotes the Increase in Magnitude of Salt-Induced Hypertension in Male Sprague-Dawley Rats.
Oloyo, A.K; Harikrishnan, V.S.; Sofola, O.A, & Anigbogu, C.N

Abstract

Blood pressure has been reported to be consistently higher in males compared with females from puberty onwards and men show an increased risk for hypertension compared to women, a risk that interacts with genes and with diet. Experiments were designed to assess the effect of testosterone deficiency on blood pressure in male Sprague-Dawley rats on normal or high salt diet. Weanling male rats were randomly divided into 8 groups (n = 6 each) that were either orchidectomised or sham-operated (under ketamine and xylazine anaesthesia), with or without testosterone replacement (10mg/kg sustanon 250® i.m once in 3 weeks), and were placed on normal (0.3%) or high (8%) NaCl diet for 6 weeks. Arterial blood pressure was determined before and weekly throughout the experimental period using non-invasive tail cuff method. There was a significant increase (P < 0.001) in the mean arterial blood pressure of rats placed on high salt diet when compared with control or orchidectomised rats. Orchidectomy elicited a reduction in MABP while testosterone replacement normalized MABP to values observed in intact rats placed on high salt diet. Endogenous testosterone promotes blood pressure-elevating effect of a high salt diet.

Keywords
Orchidectomy, Testosterone Supplementation, Salt-induced Hypertension, Blood Pressure

 
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