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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 14, No. 1, 2011, pp. 43-47
Bioline Code: md11007
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 14, No. 1, 2011, pp. 43-47

 en Antiulcerogenic Activity of Ethanolic Leaf Extract of Croton Zambesicus check for this species in other resources Muell. Arg
Okokon, Jude E.; Umoh, Uwem F.; Udobang, John A. & Etim, Emmanuel I.

Abstract

Croton Zambesicus check for this species in other resources Muell. Arg. is often used in traditional medicine by Ibibios of Niger Delta region of Nigeria for the treatment of several diseases including gastrointestinal disorders especially ulcer. The antiulcer activity of the ethanolic extract of the crude leaf extract was investigated against indomethacin, ethanol and histamine – induced ulcer models in rats. The crude leaf extract of Croton zambesicus (200 – 600mg/kg) significantly (p<0.001) inhibited ulcers produced by the ulcerogens used; indomethacin, ethanol and histamine.The results of this work suggest that the leaf extract of Croton zambesicus possesses antiulcer activity, supporting the ethnomedical use of the plant.

Keywords
Do Croton zambesicus, antiulcer, gastroprotective

 
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