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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 14, No. 1, 2011, pp. 63-68
Bioline Code: md11010
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 14, No. 1, 2011, pp. 63-68

 en Antimicrobial and Pharmaceutical Properties of The Seed Oil of Leucaena leucocephala check for this species in other resources (Lam.) De Wit (Leguminosae)
Aderibigbe, S. A.; Adetunji, O. A. & Odeniyi, M. A.

Abstract

The seed oil of Leuconia leucocephala check for this species in other resources was investigated for its antimicrobial activity and the pharmaceutical properties of its lotion formulation determined. The oil was extracted from the pulverised dried seeds of the Leuconia leucocephala plant by cold maceration in n-hexane. The oil was tested against four bacteria ( Staphylococcus aureus check for this species in other resources , Esherichia coli check for this species in other resources , Bacillus subtilis check for this species in other resources and Pseudomonas aeruginosa check for this species in other resources ) and four fungi ( Aspergilus niger check for this species in other resources , Rhizopus stolon check for this species in other resources , Penicillum notatum check for this species in other resources and Candida albicans check for this species in other resources ) isolates. Gentamycin and tioconazole were the reference drugs respectively. The oil was later formulated as a lotion and the pharmaceutical properties of the formulation determined.The oil was found to have a concentration-dependent activity against both Gram-positive and Gram-negative bacteria, while showing no activity against the fungi tested. The lotion formulation of the oil containing oleic acid had good pharmaceutical properties and was stable over the test period. Leucaena leucocephala seed oil extract had a concentration-dependent activity against both Gram-positive and Gram-negative bacteria and the lotion formulation had good pharmaceutical properties.

Keywords
Leucaena leucocephala oil, antimicrobial activity, lotion formulation

 
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