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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 14, No. 1, 2011, pp. 69-72
Bioline Code: md11011
Full paper language: English
Document type: Short Communication
Document available free of charge

African Journal of Biomedical Research, Vol. 14, No. 1, 2011, pp. 69-72

 en Adrenergic Component of Nicotine Antinociception in Rats
Ibironke, G.F & Oyekunle, O.A

Abstract

It has been widely established that nicotine , the active pharmacological agent in tobacco has antinociceptive effects , but the mechanism of this activity is yet to be fully investigated . The present study examined the effects of two adrenergic receptor antagonists , propranolol and prazosin .on nicotine antinociception using the hot plate (HP) paradigm in adult male Wister rats ( 180-220gm ) . Three groups of rats received respectively , first , saline ( 10ml/kg) intraperitoneally ( ip) plus intravenous ( iv) nicotine (1ml/kg ) , second , propranolol ( 10-30mg/kg, ip ) plus nicotine and the last group had prazosin (0.2- 1.0mg/kg , ip ) followed by the same dose of nicotine .Nociception was measured at 15 mins intervals for one hour . While the administration of normal saline had no effect on the supraspinally mediated hot plate latencies , both propranolol and prazosin reduced the hot plate responses ( significant at 15 , 30 ,45 and 60 mins , post injection) .These findings suggest the involvement of the adrenergic system in nicotine induced antinociception .

Keywords
propranolol, prazosin, antinociception, hot plate

 
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