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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 14, No. 3, 2011, pp. 209-212
Bioline Code: md11034
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 14, No. 3, 2011, pp. 209-212

 en Anti-inflammatory and Analgesic Effects of Aqueous Extract of Aloe Vera ( Aloe barbadensis check for this species in other resources ) in Rats
Egesie, U.G.; Chima, K.E. & Galam, N.Z.


The anti-inflammatory and analgesic activities of aqueous extract of Aloe barbadensis check for this species in other resources was investigated in rats. Formalin- induced hind paw oedema was used to assess the anti- inflammatory activity of the extract while acetic acid-induced abdominal writhing was used for analgesic activity. The results of the anti-inflammatory study revealed that 25, 50 and 100 mg/kg of the extract reduced the formalin-induced oedema significantly (P <0.05) at the beginning of 3 hours when compared to the control group. In the analgesic study, 25, 50 and 100 mg/kg of extract significantly (P <0.5) reduced the number of writhes induced by a 0.6% Acetic acid solution with an approximately 66.49%, 57.59% and 68.06% inhibition respectively. The present study showed that the aqueous extract of Aloe barbadensis has anti-inflammatory and analgesic activities that could be mediated via modulators of pain and inflammation or through central activity.

Aloe barbadensis; anti-inflammatory; analgesic activity

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