search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 15, No. 1, 2012, pp. 55-58
Bioline Code: md12009
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 15, No. 1, 2012, pp. 55-58

 en Effects of Coartem and Artesunate on Some Haematological and Biochemical Parameters in Albino Rats
Adeleye, G.S.; Nneli, R.; Nwozor, C.M & Emesiana, M.C

Abstract

The effects of Coartem and Artesunate on the hematological and biochemical parameters of albino rats were investigated. Rats were given 0.57ml of 5.6mg/ml of coartem solution, (20mg artemeter and 120 mg lumefantrine) (group 1) and 0.6ml of 0.5mg/ml of artesunate solution (group 2). Group 3 was control. 5.0 mls of blood sample were collected from the rats through cardiac puncture into EDTA bottle for hematological analysis and 4 mls into plain bottles for biochemical analysis. The findings of this present study show that coartem and artesunate have effects on the hematological and biochemical parameters in albino rats. The hematological indices evaluated were RBC, WBC, differential WBC; Hb, and PCV. Biochemical parameters included Cl K, Na. HCO3, creatinine and total protein. Artesunate and coartem had significant effects on the blood levels of white blood cells, neutrophils and lymphocytes without significant effects on other hematological parameters measured. WBC and lymphocyte were increased neutrophils was decreased These changes were within tolerable limits.

Keywords
Coartem, artesunate, lymphocytes, neutrophils, biochemical parameter

 
© Copyright 2012 - Ibadan Biomedical Communications Group

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2017, Site last up-dated on 16-Oct-2017.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil