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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 15, No. 2, 2012, pp. 129-133
Bioline Code: md12020
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 15, No. 2, 2012, pp. 129-133

 en Anti-bacterial activity of Extract of Crinum jagus check for this species in other resources bulb against Isolates of Mycobacterium tuberculosis check for this species in other resources
Kehinde, A.O. & Akintola, A. O

Abstract

Crinum jagus check for this species in other resources plant has been reportedly used for treatment of infectious diseases in Nigeria. In this study, the antibacterial activity of the crude extract and chromatographic fractions from the bulb of Crinium jagus against Mycobacterium tuberculosis check for this species in other resources isolates was investigated using Lowenstein-Jensen medium (LJ) and Middlebrook 7H10 agar. Colony forming unit (cfu) was determined and percentage inhibition calculated by mean reduction in number of colonies on extract containing medium as compared to extract free control medium. The highest inhibition rate of 59% representing 56 cfu was observed for M. tuberculosis isolate 3 in Middlebrook 7H10 medium while similar rate of 57% was obtained on LJ medium. Fraction F3 showed 86% inhibition activity at 1.0mg/ml concentration in Middlebrook 7H10 agar compared with fractions F4 and F5 which showed 63% and 73% inhibition rates respectively. Even though, higher inhibition rates were observed with Middlebrook 7H10 agar as compared with LJ medium the difference was not statistically significant (p>0.05). The results support the folkloric use of Crinum jagus in the treatment of microbial infections and suggest that the plant may be beneficial in the treatment of tuberculosis.

Keywords
Crinum jagus, Mycobacterium tuberculosis, infection

 
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