Chrysophyllum albidum
is a tropical plant in Southern Nigeria. Methanol extract of
Chrysophyllum albidum bark (
MeCaB) has been reported to have antiplasmodial, haematinic and membrane stabilizing properties. The mechanism by which
MeCaB exerts these properties is yet to be elucidated. This study therefore seeks to investigate the probable mechanism of its haematinic potential on the bone marrow in two separate anaemic studies. Mice were inoculated with
Plasmodium Berghei
berghei while others were made anaemic by bleeding out 0.25mls of blood through the retro-orbital plexus. Smears of the femoral bone marrow from each group were prepared on days 3 and 7 of extract/drug treatment for blood precursor cell evaluation (myeloid: erythroid ratio; M:E). Groups parasitized and treated continuously for 3 days with
MeCaB (
PMeCaB) had significantly reduced M: E ratio (
1.88+0.03) compared with parasitized untreated group (
PUn) (
2.33+0.00). Withdrawal of treatment with
MeCaB, it’s fractions (
CFr 1,2,3) and chloroquine from parasitized animals between days 4 to 7 showed significant increase in M:E ratio of
PUn (
5.13+0.59) and
PCqi (
4.11+0.37) compared with
PCFr 1 and 3 (
1.21+0.08 and 1.69+0.00 respectively). The
MeCaB only treated and group bled and treated with
MeCaB (
BMeCaB) continuously for 7 days had significantly reduced M:E ratio (
1.67+0.00 and 1.35+0.00 respectively) compared with control, bled and treated with haematinic (
2.13+0.19, 2.25+0.21 respectively). This study thus establishes that
Chrysophyllum albidum exerts haematinic properties on bone marrow cells by stimulating the production of more erythroid series which reverted anaemia induced by
plasmodium berghei berghei and bleeding out.