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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 18, No. 1, 2015, pp. 43-47
Bioline Code: md15007
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 18, No. 1, 2015, pp. 43-47

 en Therapeutic Efficacy Of Cotecxin(R) alone and Its Combination with Diminazene aceturate (Berenil(B)) in the Treatment of Experimental Trypanosoma brucei brucei Infection of Rats
Egbe-Nwiyi, T.N. & Yakubu, C.

Abstract

The therapeutic efficacy of Cotecxin(R)(Dihydroartemisinin) alone and its combination with diminazene aceturate (Berenil(R))was studied in rats infected with Federe strain of Trypanosoma brucei brucei. Fifty healthy adult albino rats of both sexes weighing between 100-180g used were divided into five groups (A-E) of 10 rats each. Rats in groups A-D were each infected with T.b. brucei (1x106 trypanosomes). Rats in groups A were treated with 7.0mg/Kg of diminazene aceturate (Berenil(R)) as a single dose, group B with 1.0mg/Kg of Cotecxin(R)and group C with a combination of diminazene aceturate (3.5mg/Kg) and Cotecxin(R)(1.0mg/Kg). Rats in group D remained untreated while group E animals served as the uninfected and untreated control. The pre-patent periods in groups A, B, C and D were 3.5 ± 0.9, 3.1 ± 0.9, 3.2 ± 0.6 and 3.5 ± 0.9 days respectively. There was no significant difference in pre-patent periods among the infected groups. The infected rats were treated on day 6 post-infection (Pi). Survival time was 26.6 ± 0.5 and 15.8 ± 1.6 days in groups B and D respectively and shorter (P <0.05) in group D. Cotecxin(R)treatment alone suppressed level of parasitaemia, prolonged survival time but could not completely clear the parasites from the blood. Complete clearance of the parasites was achieved in groups A and C rats as there was no relapse. In conclusion, Cotecxin(R) alone was not effective but its combination with diminazene aceturate(Berenil(R)) was effective in Trypanosoma brucei brucei clearance from the blood.

Keywords
Cotecxin(R); diminazene aceturate; Trypanosoma brucei brucei; rats

 
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