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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 19, No. 1, 2016, pp. 55-60
Bioline Code: md16008
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 19, No. 1, 2016, pp. 55-60

 en EVALUATION OF THE ANTI-FUNGAL PROPERTIES OF EXTRACTS OF Daniella oliveri
Coker, M. E. & Ogundele, O. S.

Abstract

The in vitro anti-fungal activity of leaf and stem bark of Daniella oliveri Rolfe was investigated against selected yeasts and moulds including dermatophytes. Water and methanol were used to extract the powdered leaf and stem bark using cold infusion. Antimicrobial activity was assessed by agar-well diffusion. Phytochemical analysis was carried out using standard procedures. The plant extracts were active against the test organisms at concentrations ranging from 3.125-100 mg/mL. The methanol extracts were more active than the aqueous extracts with the highest inhibition against the yeasts, Candida albicans check for this species in other resources and Candida krusei check for this species in other resources (MIC values of 3.125 mg/mL and 6.25 mg/mL respectively). Epidermophyton floccosum check for this species in other resources and Trichophyton interdigitale check for this species in other resources were the least inhibited of all the fungal strains. Phytochemical screening revealed the presence of tannins, anthraquinones, flavonoids, cardiac glycosides, alkaloids and saponins. The anti-fungal activity of Daniella oliveri as shown in this study indicates that the plant has the potential of utilisation in the development of chemotherapeutic agents for the treatment of relevant fungal infections.

Keywords
Daniella oliveri; leaf and stem bark; anti-fungal activity; secondary metabolites

 
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